MED12L

Across TCGA patient cohorts, MED12L mutation is significantly associated with the RNA expression of many other genes, with 8,184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED12L-associated genes across cancer lineages are KCTD9, RFC5, and KIF11. Each is linked with MED12L in more than 5 cancer types. Because this analysis shows association rather than direction, both MED12L-to-partner and partner-to-MED12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by MED12L-low versus MED12L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12L→partner) and Y-score (partner→MED12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.624	+1.377	<.001	<.001	3	6
LUAD	RFC5 →	+0.447	+2.736	.004	.003	3	6
LUAD	KIF11 →	+0.715	+2.602	.003	.006	3	6
COAD	NDC80 →	+0.545	+3.598	.001	.001	3	6
LUAD	CDKN3 →	+0.835	+2.611	.002	.005	3	5
LUAD	CENPI →	+0.736	+2.514	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,184 associations by consensus.

KCTD9 by MED12L expression — UCEC

Explore this box plot interactively →