MED12L

Across TCGA patient cohorts, MED12L mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED12L-associated genes across cancer lineages are eIF4E, Bad_pS112, and ACC1. Each is linked with MED12L in more than 2 cancer types. Because this analysis shows association rather than direction, both MED12L-to-partner and partner-to-MED12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MED12L-low versus MED12L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12L→partner) and Y-score (partner→MED12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.221	+3.459	.006	.005	3	3
STAD	Bad_pS112 →	-0.193	-3.321	.041	.009	3	3
LUAD	ACC1 →	+0.426	+2.186	.014	.032	3	3
LUAD	4E-BP1 →	+0.281	+2.584	.033	.011	3	3
LUAD	Cyclin-B1 →	+0.627	+3.000	.003	.035	3	3
COAD	GAPDH →	+0.551	+1.708	.004	.026	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

eIF4E by MED12L expression — STAD

Explore this box plot interactively →