MED12L

Across TCGA cell cohorts, MED12L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,196 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED12L-associated GO terms across cancer lineages are Regulation of DNA repair, RNA export from nucleus, and Positive regulation of DNA recombination. Each is linked with MED12L in more than 14 cancer types. Because this analysis shows association rather than direction, both MED12L-to-partner and partner-to-MED12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by MED12L-low versus MED12L-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12L→partner) and Y-score (partner→MED12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of DNA repair →	+0.082	+1.386	<.001	.004	3	15
OESOPHAGUS	RNA export from nucleus →	+0.118	+0.860	.001	.007	3	14
OVARY	Positive regulation of DNA recombination →	+0.065	+0.747	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.069	+0.801	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.070	+0.732	<.001	<.001	3	13
OESOPHAGUS	Positive regulation of double-strand break repair via homologous recombination →	+0.076	+1.137	.006	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,196 associations by consensus.

Regulation of DNA repair by MED12L expression — OESOPHAGUS

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