MED12L

Across TCGA cell cohorts, MED12L mutation is significantly associated with the RNA expression of many other genes, with 1,381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED12L-associated genes across cancer lineages are OVCA2, NT5C1A, and CCDC134. Each is linked with MED12L in more than 2 cancer types. Because this analysis shows association rather than direction, both MED12L-to-partner and partner-to-MED12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OVCA2 grouped by MED12L-low versus MED12L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12L→partner) and Y-score (partner→MED12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OVCA2 →	+0.359	+1.409	.007	.005	3	3
BREAST	NT5C1A →	+0.113	+2.940	<.001	.007	3	2
LARGE_INTESTINE	CCDC134 →	+0.795	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	CENPM →	+0.720	+2.321	<.001	<.001	3	2
LARGE_INTESTINE	ADNP2 →	+0.767	+1.969	<.001	<.001	3	2
LARGE_INTESTINE	TRIM37 →	+0.474	+1.584	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,381 associations by consensus.

OVCA2 by MED12L expression — LARGE_INTESTINE

Explore this box plot interactively →