Across TCGA patient cohorts, MED12 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,554 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MED12-associated proteins across cancer lineages are GATAD2B, NONO, and SMC3. Each is linked with MED12 in more than 6 cancer types. Because this analysis shows association rather than direction, both MED12-to-partner and partner-to-MED12 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12→partner) and Y-score (partner→MED12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GATAD2B →	+0.281	+0.435	.004	.006	3	7
GBM	NONO →	+0.206	+0.443	<.001	<.001	3	6
GBM	SMC3 →	+0.313	+0.464	<.001	<.001	3	6
LSCC	ADNP →	+0.362	+0.543	<.001	<.001	3	6
HNSC	RCOR3 →	+0.460	+0.597	<.001	<.001	3	5
HNSC	HCFC1 →	+0.258	+0.542	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,554 associations by consensus.

Exploration

MED12 survival (RNA) · tumor vs normal (RNA) · all MED12 data types