Across TCGA patient cohorts, MED12 mutation is significantly associated with the RNA expression of many other genes, with 6,646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED12-associated genes across cancer lineages are PIMREG, MND1, and PPIP5K2. Each is linked with MED12 in more than 5 cancer types. Because this analysis shows association rather than direction, both MED12-to-partner and partner-to-MED12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12→partner) and Y-score (partner→MED12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PIMREG →	+0.712	+2.213	.001	<.001	3	6
LUAD	MND1 →	+0.516	+1.596	.003	.006	3	6
CESC	PPIP5K2 →	+0.462	+3.936	.001	<.001	3	5
UCEC	C1orf174 →	+0.236	+1.537	<.001	<.001	3	5
STAD	EZH2 →	+0.645	+3.195	.005	.009	3	5
STAD	CCNB1 →	+0.759	+3.182	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,646 associations by consensus.

Exploration

MED12 survival (RNA) · tumor vs normal (RNA) · all MED12 data types