Across TCGA cell cohorts, MED12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,787 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MED12-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Regulation of transcription initiation by RNA polymerase II. Each is linked with MED12 in more than 17 cancer types. Because this analysis shows association rather than direction, both MED12-to-partner and partner-to-MED12 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED12→partner) and Y-score (partner→MED12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA-templated transcription initiation →	+0.066	+1.363	.006	.008	2	18
BREAST	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.188	+1.040	<.001	<.001	3	17
LUNG_SCLC	Regulation of transcription initiation by RNA polymerase II →	+0.072	+0.826	<.001	.002	3	17
BONE	Epigenetic regulation of gene expression →	+0.093	+1.460	<.001	.005	3	16
BONE	Nucleic acid transport →	+0.121	+0.885	<.001	.002	3	16
BONE	RNA transport →	+0.121	+0.885	<.001	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,787 associations by consensus.

Exploration

MED12 survival (RNA) · tumor vs normal (RNA) · all MED12 data types