MED10

Across TCGA patient cohorts, MED10 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED10-associated genes across cancer lineages are RNU6-622P, RNA5SP412, and RNA5SP164. Each is linked with MED10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED10-to-partner and partner-to-MED10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-622P grouped by MED10-low versus MED10-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED10→partner) and Y-score (partner→MED10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-622P →	+0.248	+8.471	<.001	.005	3	2
UCEC	RNA5SP412 →	+1.739	+4.552	<.001	.005	3	1
BRCA	RNA5SP164 →	+0.299	+8.471	<.001	.005	3	1
UCEC	MIR4711 →	+0.709	+4.771	<.001	.006	3	1
UCEC	ATP6V1E1P2 →	+0.411	+4.661	<.001	.004	3	1
LUSC	RNU6-1277P →	+0.328	+4.548	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RNU6-622P by MED10 expression — BRCA

Explore this box plot interactively →