MED1

Across TCGA cell cohorts, MED1 mutation is significantly associated with the mutation status of many other genes, with 4,233 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED1-associated genes across cancer lineages are ZNF768, MAST1, and RGS3. Each is linked with MED1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MED1-to-partner and partner-to-MED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF768 grouped by MED1-low versus MED1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED1→partner) and Y-score (partner→MED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF768 →	+4.297	+4.857	.009	.009	1	5
BLOOD_Leukemia	MAST1 →	+3.039	+3.640	<.001	<.001	1	4
SKIN	RGS3 →	+3.532	+3.357	.005	.005	1	4
BLOOD_Leukemia	MGAT3 →	+4.531	+3.565	<.001	<.001	1	4
BLOOD_Lymphoma	POLR2A →	+3.977	+4.238	<.001	<.001	1	4
BLOOD_Leukemia	MYBPC1 →	+4.209	+3.285	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,233 associations by consensus.

ZNF768 by MED1 expression — BREAST

Explore this box plot interactively →