MEAF6

Across TCGA patient cohorts, MEAF6 mutation is significantly associated with the RNA expression of many other genes, with 1,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEAF6-associated genes across cancer lineages are RNU6-178P, RNA5SP419, and RNU6-1276P. Each is linked with MEAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEAF6-to-partner and partner-to-MEAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-178P grouped by MEAF6-low versus MEAF6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEAF6→partner) and Y-score (partner→MEAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-178P →	+0.797	+4.437	<.001	.002	3	2
UCEC	RNA5SP419 →	+0.570	+2.340	.001	.003	3	2
COAD	RNU6-1276P →	+0.228	+4.666	<.001	.005	3	1
COAD	RNU6-540P →	+0.600	+3.681	<.001	.009	3	1
COAD	RNA5SP163 →	+0.258	+5.824	<.001	.001	3	1
COAD	RNA5SP304 →	+0.462	+5.020	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,241 associations by consensus.

RNU6-178P by MEAF6 expression — COAD

Explore this box plot interactively →