ME3

Across TCGA patient cohorts, ME3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ME3-associated genes across cancer lineages are JNK_pT183_Y185, Tuberin_pT1462, and Bak. Each is linked with ME3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ME3-to-partner and partner-to-ME3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ME3-low versus ME3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ME3→partner) and Y-score (partner→ME3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.167	-3.700	.005	.001	3	2
UCEC	Tuberin_pT1462 →	+0.302	+1.775	<.001	.007	3	2
UCEC	Bak →	+0.201	+1.925	.026	.005	3	2
UCEC	Cyclin-E2 →	+0.179	+2.906	.003	.001	3	2
UCEC	14-3-3_beta →	-0.082	-3.558	.023	.002	3	1
UCEC	eIF4E →	+0.177	+1.925	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

JNK_pT183_Y185 by ME3 expression — UCEC

Explore this box plot interactively →