ME3

Across TCGA cell cohorts, ME3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ME3-associated genes across cancer lineages are HBG1, RAX, and DUSP29. Each is linked with ME3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ME3-to-partner and partner-to-ME3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBG1 grouped by ME3-low versus ME3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ME3→partner) and Y-score (partner→ME3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HBG1 →	+0.566	+4.029	<.001	.009	3	2
BREAST	RAX →	+0.011	+4.421	<.001	.004	3	1
BREAST	DUSP29 →	+0.440	+4.781	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	OTOP1 →	+0.604	+3.762	<.001	.003	3	1
OVARY	LACTBL1 →	+0.044	+4.700	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

HBG1 by ME3 expression — OVARY

Explore this box plot interactively →