ME2

Across TCGA patient cohorts, ME2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,616 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ME2-associated proteins across cancer lineages are PIK3AP1, GBP5, and PARVG. Each is linked with ME2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ME2-to-partner and partner-to-ME2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ME2 versus PIK3AP1 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ME2→partner) and Y-score (partner→ME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3AP1 →	+0.535	+0.336	<.001	<.001	3	6
COAD	GBP5 →	+0.832	+0.840	<.001	<.001	3	6
COAD	PARVG →	+0.449	+0.582	.004	.003	2	6
COAD	HCK →	+0.585	+0.931	<.001	<.001	3	5
UCEC	HAUS4 →	+0.324	+0.374	<.001	.002	3	5
BRCA	TMX3 →	+0.391	+0.524	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,616 associations by consensus.

ME2 vs PIK3AP1 — GBM

Explore this scatter interactively →