ME1

Across TCGA patient cohorts, ME1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ME1-associated genes across cancer lineages are Chk1, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with ME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ME1-to-partner and partner-to-ME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by ME1-low versus ME1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ME1→partner) and Y-score (partner→ME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.152	+1.519	.014	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.533	+1.652	.006	.006	3	2
UCEC	4E-BP1 →	+0.216	+1.837	.015	.014	3	2
SKCM	p90 RSK →	+0.187	+1.678	.005	.020	3	1
SKCM	BRD4 →	-0.323	-2.970	.017	.030	3	1
SKCM	53BP1 →	-0.348	-2.502	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Chk1 by ME1 expression — SKCM

Explore this box plot interactively →