ME1

Across TCGA pan-cancer cohorts, ME1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ME1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ME1 RNA is repressed in tumor relative to normal tissue. In most cancer types ME1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where ME1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ME1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−2.512	<.001	9	view →
COAD	Male	II,III,IV	+1.182	<.001	9	view →
BRCA	All	All	−1.071	<.001	6	view →
KIRP	All	II,III,IV	+1.324	.002	5	view →
KICH	All	II,III,IV	−1.167	.002	5	view →
LIHC	All	All	+0.964	<.001	5	view →
LUSC	Male	All	+1.061	<.001	4	view →
KIRC	All	IV	+0.806	.008	4	view →
STAD	All	All	−0.663	.009	3	view →
LUAD	All	All	+0.458	.001	3	view →
PRAD	All	All	−1.347	<.001	2	view →
UCEC	All	All	−0.989	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ME1–THCA

Open the THCA breakdown →