ME1

Across TCGA cell cohorts, ME1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,786 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ME1-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, and Regulation of protein exit from endoplasmic reticulum. Each is linked with ME1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ME1-to-partner and partner-to-ME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by ME1-low versus ME1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ME1→partner) and Y-score (partner→ME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cotranslational protein targeting to membrane →	+0.094	+2.177	<.001	<.001	3	10
SKIN	SRP-dependent cotranslational protein targeting to membrane →	+0.105	+1.465	<.001	<.001	3	9
SOFT_TISSUE	Regulation of protein exit from endoplasmic reticulum →	+0.106	+2.724	<.001	<.001	3	9
SOFT_TISSUE	Establishment of protein localization to endoplasmic reticulum →	+0.071	+2.499	.001	<.001	3	9
OVARY	Positive regulation of protein exit from endoplasmic reticulum →	+0.090	+1.742	<.001	.004	3	9
BONE	Regulation of translation in response to stress →	+0.098	+1.364	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

Cotranslational protein targeting to membrane by ME1 expression — OVARY

Explore this box plot interactively →