ME1

Across TCGA cell cohorts, ME1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ME1-associated genes across cancer lineages are RPL10L, OR52J3, and TDRD15. Each is linked with ME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ME1-to-partner and partner-to-ME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL10L grouped by ME1-low versus ME1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ME1→partner) and Y-score (partner→ME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR52J3 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	TDRD15 →	+0.029	+4.930	<.001	.008	3	1
SOFT_TISSUE	CARD17 →	+0.376	+5.977	<.001	.001	3	1
OESOPHAGUS	OR10A5 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

RPL10L by ME1 expression — SOFT_TISSUE

Explore this box plot interactively →