Across TCGA patient cohorts, MDM4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,984 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MDM4-associated proteins across cancer lineages are CHAMP1, GATAD2B, and POGZ. Each is linked with MDM4 in more than 7 cancer types. Because this analysis shows association rather than direction, both MDM4-to-partner and partner-to-MDM4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM4→partner) and Y-score (partner→MDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHAMP1 →	+0.382	+0.804	<.001	<.001	3	8
HNSC	GATAD2B →	+0.388	+0.927	<.001	<.001	3	8
GBM	POGZ →	+0.385	+0.809	<.001	<.001	3	8
UCEC	RPRD2 →	+0.266	+0.638	<.001	<.001	3	7
HNSC	CHAMP1_S204 →	+0.363	+0.643	<.001	<.001	1	8
HNSC	GABPA →	+0.309	+0.827	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,984 associations by consensus.

Exploration

MDM4 survival (RNA) · tumor vs normal (RNA) · all MDM4 data types