Across TCGA patient cohorts, MDM4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,547 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDM4-associated genes across cancer lineages are MUC5B, UTP23, and CATSPER2P1. Each is linked with MDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM4-to-partner and partner-to-MDM4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM4→partner) and Y-score (partner→MDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MUC5B →	+3.755	+1.162	<.001	<.001	3	2
PDAC	UTP23 →	-0.384	-1.673	.001	<.001	3	2
UCEC	CATSPER2P1 →	-0.471	-0.533	<.001	.006	3	2
LSCC	LINC02572 →	-0.255	-0.451	.002	.001	3	2
UCEC	RN7SL740P →	-0.464	-0.831	.003	<.001	3	2
BRCA	TMEM249 →	-0.265	-0.472	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,547 associations by consensus.

Exploration

MDM4 survival (RNA) · tumor vs normal (RNA) · all MDM4 data types