Across TCGA patient cohorts, MDM4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDM4-associated genes across cancer lineages are FoxM1, MEK1, and p90 RSK. Each is linked with MDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM4-to-partner and partner-to-MDM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM4→partner) and Y-score (partner→MDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.343	+3.700	.004	.001	3	1
UCEC	MEK1 →	+0.417	+3.321	.014	.010	3	1
UCEC	p90 RSK →	+0.176	+1.887	.048	.031	3	1
UCEC	Rad50 →	-0.311	-3.700	.005	.001	3	1
UCEC	Annexin-1 →	+0.536	+2.827	.029	.035	3	1
UCEC	Tuberin_pT1462 →	+0.211	+2.331	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

MDM4 survival (RNA) · tumor vs normal (RNA) · all MDM4 data types