Across TCGA cell cohorts, MDM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,856 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDM4-associated GO terms across cancer lineages are Pre-mRNA catabolic process, RNA catabolic process, and Positive regulation of double-strand break repair. Each is linked with MDM4 in more than 16 cancer types. Because this analysis shows association rather than direction, both MDM4-to-partner and partner-to-MDM4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM4→partner) and Y-score (partner→MDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.222	+1.448	<.001	<.001	3	17
BONE	RNA catabolic process →	+0.087	+1.405	<.001	<.001	3	16
OESOPHAGUS	Positive regulation of double-strand break repair →	+0.084	+1.243	<.001	.001	3	16
BONE	mRNA catabolic process →	+0.070	+1.249	.001	.001	3	16
OESOPHAGUS	Cilium movement involved in cell motility →	-0.112	-1.055	<.001	.002	3	16
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.104	-0.921	<.001	.006	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,856 associations by consensus.

Exploration

MDM4 survival (RNA) · tumor vs normal (RNA) · all MDM4 data types