Across TCGA cell cohorts, MDM4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDM4-associated genes across cancer lineages are SLC32A1, PHOX2B, and APOL5. Each is linked with MDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM4-to-partner and partner-to-MDM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM4→partner) and Y-score (partner→MDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.904	+3.223	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.022	+4.687	<.001	<.001	3	1
BLOOD_Leukemia	APOL5 →	+0.014	+3.890	<.001	<.001	3	1
BLOOD_Leukemia	CCKAR →	+0.026	+3.239	<.001	.004	3	1
BLOOD_Leukemia	FBXW10 →	+0.061	+3.540	<.001	.005	3	1
BLOOD_Leukemia	KPNA7 →	+0.362	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

MDM4 survival (RNA) · tumor vs normal (RNA) · all MDM4 data types