MDH1B

Across TCGA patient cohorts, MDH1B protein abundance is significantly associated with the RNA expression of many other genes, with 4,720 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MDH1B-associated genes across cancer lineages are SPTLC2, CERT1, and KAT2B. Each is linked with MDH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MDH1B-to-partner and partner-to-MDH1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDH1B versus SPTLC2 in LSCC, with a Pearson correlation of -0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1B→partner) and Y-score (partner→MDH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPTLC2 →	-0.990	-0.566	.006	.002	2	1
LSCC	CERT1 →	-0.685	-0.600	<.001	.007	2	1
LSCC	KAT2B →	-0.878	-0.566	.002	.002	2	1
LSCC	ACE2 →	-0.348	-0.566	.004	.002	2	1
LSCC	TRPM4 →	-0.615	-0.600	.007	.007	2	1
LSCC	TMEM243 →	-0.588	-0.566	.002	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,720 associations by consensus.

MDH1B vs SPTLC2 — LSCC

Explore this scatter interactively →