MDH1B

Across TCGA pan-cancer cohorts, MDH1B RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MDH1B data layer compared with 7 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MDH1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated MDH1B expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

BRCA, LIHC, and READ are the cancer types where MDH1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.940	0.861	.001	74	view →
LIHC	DFS	Tertile	All	0.320	0.474	.001	37	view →
READ	OS	Quartile	All	1.000	0.802	.001	23	view →
UVM	DFS	Quartile	III,IV	0.313	0.900	.013	21	view →
LGG	OS	Quartile	All	0.705	0.827	.009	15	view →
SARC	DFS	Tertile	All	0.699	0.502	.015	14	view →
HNSC	DFS	Median	III,IV	0.393	0.592	.025	14	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	10	view →
OV	DFS	Tertile	All	0.585	0.507	.031	8	view →
CESC	OS	Tertile	IV	0.863	0.119	.020	6	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →
LUSC	DFS	Quartile	All	0.751	0.498	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MDH1B–BRCA (OS)

Open the BRCA breakdown →