MDH1B

Across TCGA patient cohorts, MDH1B mutation is significantly associated with the RNA expression of many other genes, with 1,892 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDH1B-associated genes across cancer lineages are ZMYND19, RNF126, and NDUFA6. Each is linked with MDH1B in more than 2 cancer types. Because this analysis shows association rather than direction, both MDH1B-to-partner and partner-to-MDH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYND19 grouped by MDH1B-low versus MDH1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1B→partner) and Y-score (partner→MDH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZMYND19 →	+0.511	+2.186	<.001	.001	3	3
UCEC	RNF126 →	+0.413	+1.769	.001	.004	3	3
UCEC	NDUFA6 →	+0.555	+3.021	<.001	<.001	3	3
UCEC	ZNF782 →	+0.296	+2.124	.008	<.001	3	3
READ	RNU6-178P →	+0.565	+4.361	.001	.006	3	2
READ	LINC02319 →	+0.237	+4.827	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,892 associations by consensus.

ZMYND19 by MDH1B expression — UCEC

Explore this box plot interactively →