MDH1B

Across TCGA patient cohorts, MDH1B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDH1B-associated genes across cancer lineages are S6_pS240_S244, XBP1, and EGFR_pY1068. Each is linked with MDH1B in more than 2 cancer types. Because this analysis shows association rather than direction, both MDH1B-to-partner and partner-to-MDH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by MDH1B-low versus MDH1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1B→partner) and Y-score (partner→MDH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.387	+2.115	.008	.017	3	3
SKCM	XBP1 →	-0.253	-2.000	.021	.031	3	2
UCEC	EGFR_pY1068 →	-0.261	-1.925	.003	.005	3	2
UCEC	ERK2 →	+0.169	+2.115	.014	.016	3	2
UCEC	FoxM1 →	+0.224	+1.584	.016	.019	3	2
UCEC	MEK1 →	+0.405	+2.415	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

S6_pS240_S244 by MDH1B expression — UCEC

Explore this box plot interactively →