MDH1B

Across TCGA cell cohorts, MDH1B mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDH1B-associated genes across cancer lineages are Uprosertib, PRT062607, and Alisertib. Each is linked with MDH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MDH1B-to-partner and partner-to-MDH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Uprosertib grouped by MDH1B-low versus MDH1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1B→partner) and Y-score (partner→MDH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Uprosertib →	+0.717	+2.646	.017	.047	2	1
LARGE_INTESTINE	PRT062607 →	+0.538	+2.769	.033	.040	2	1
LARGE_INTESTINE	Alisertib →	+0.876	+2.646	.014	.047	1	1
LARGE_INTESTINE	EPZ004777 →	+0.434	+2.893	.005	.034	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Uprosertib by MDH1B expression — LARGE_INTESTINE

Explore this box plot interactively →