MDFI

Across TCGA pan-cancer cohorts, MDFI RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MDFI data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MDFI RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDFI expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

UVM, KIRP, and LUAD are the cancer types where MDFI RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.422	0.718	<.001	98	view →
KIRP	OS	Median	II,III,IV	0.339	0.724	<.001	92	view →
LUAD	OS	Median	All	0.260	0.436	<.001	80	view →
SKCM	OS	Median	All	0.834	0.907	<.001	71	view →
ACC	DFS	Quartile	All	0.150	0.720	<.001	66	view →
UCS	DFS	Tertile	All	0.594	0.206	.010	44	view →
PAAD	DFS	Median	All	0.215	0.507	<.001	42	view →
THYM	DFS	Median	All	0.884	0.642	.002	27	view →
LAML	DFS	Quartile	All	0.722	0.333	.010	16	view →
LGG	OS	Tertile	All	0.919	0.833	.001	14	view →
LUSC	DFS	Median	All	0.690	0.803	.002	12	view →
LIHC	OS	Quartile	III,IV	0.251	0.663	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MDFI–UVM (DFS)

Open the UVM breakdown →