MDFI

Across TCGA pan-cancer cohorts, MDFI RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MDFI’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MDFI RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MDFI is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where MDFI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MDFI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+3.376	<.001	11	view →
HNSC	Female	IV	+2.030	<.001	11	view →
THCA	Male	All	+2.091	<.001	9	view →
BLCA	All	III,IV	+1.633	.005	8	view →
LUAD	Male	II,III,IV	+1.537	<.001	8	view →
KICH	Male	All	−1.133	<.001	8	view →
READ	Male	All	+3.469	<.001	7	view →
LUSC	Male	All	+1.902	<.001	7	view →
STAD	Male	II,III,IV	+2.207	<.001	6	view →
LIHC	Female	All	+1.297	<.001	6	view →
CHOL	Male	All	+4.803	<.001	5	view →
BRCA	All	II,III,IV	−0.652	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MDFI–COAD

Open the COAD breakdown →