MCUB

Across TCGA pan-cancer cohorts, MCUB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MCUB data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MCUB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCUB expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where MCUB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.549	1.000	.004	34	view →
LUAD	DFS	Median	III,IV	0.681	0.314	.044	4	view →
PDAC	DFS	Quartile	All	0.661	1.000	.036	4	view →
UCEC	DFS	Tertile	All	0.820	0.975	.027	2	view →
GBM	OS	Tertile	All	0.457	0.644	.043	2	view →
HNSC	DFS	Tertile	All	1.000	0.921	.018	2	view →
LSCC	OS	Quartile	All	0.698	0.902	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MCUB–CCRCC (DFS)

Open the CCRCC breakdown →