MCUB

Across TCGA patient cohorts, MCUB mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCUB-associated genes across cancer lineages are PCNA, eEF2, and JNK2. Each is linked with MCUB in more than 1 cancer types. Because this analysis shows association rather than direction, both MCUB-to-partner and partner-to-MCUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MCUB-low versus MCUB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCUB→partner) and Y-score (partner→MCUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.203	+3.169	.031	.018	3	2
UCEC	eEF2 →	+0.357	+3.169	.022	.018	3	1
UCEC	JNK2 →	+0.188	+3.009	.030	.019	3	1
UCEC	MSH2 →	-0.217	-2.973	.031	.035	3	1
UCEC	p62 Lck ligand →	+0.430	+2.807	.002	.003	3	1
UCEC	Annexin-1 →	+0.592	+2.189	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PCNA by MCUB expression — UCEC

Explore this box plot interactively →