MCU

Across TCGA cell cohorts, MCU RNA expression is significantly associated with the go_rna of many other GO terms, with 5,166 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MCU-associated GO terms across cancer lineages are Cellular response to calcium ion starvation, Regulation of mitochondrial fission, and Positive regulation of mitochondrial ATP synthesis coupled electron transport. Each is linked with MCU in more than 19 cancer types. Because this analysis shows association rather than direction, both MCU-to-partner and partner-to-MCU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to calcium ion starvation grouped by MCU-low versus MCU-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCU→partner) and Y-score (partner→MCU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to calcium ion starvation →	+0.262	+1.127	<.001	<.001	3	20
LUNG_NSCLC_LUAD	Regulation of mitochondrial fission →	+0.102	+0.930	<.001	<.001	3	13
BLOOD_Myeloma	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.172	+0.737	.004	.004	3	12
LARGE_INTESTINE	Calcium import into the mitochondrion →	+0.130	+0.971	<.001	<.001	3	12
BONE	Positive regulation of mitochondrial fission →	+0.124	+0.863	<.001	<.001	3	12
BREAST	Regulation of actin filament polymerization →	+0.084	+1.001	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,166 associations by consensus.

Cellular response to calcium ion starvation by MCU expression — BONE

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