MCU

Across TCGA cell cohorts, MCU mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCU-associated genes across cancer lineages are TPD52L3, DYNAP, and FAM71C. Each is linked with MCU in more than 1 cancer types. Because this analysis shows association rather than direction, both MCU-to-partner and partner-to-MCU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by MCU-low versus MCU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCU→partner) and Y-score (partner→MCU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TPD52L3 →	+0.056	+4.684	<.001	.002	3	2
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
BLOOD_Leukemia	FAM71C →	+0.225	+5.060	<.001	.001	3	1
BLOOD_Leukemia	DEFB134 →	+0.017	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR2M3 →	+0.019	+4.409	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TPD52L3 by MCU expression — LARGE_INTESTINE

Explore this box plot interactively →