MCPH1

Across TCGA patient cohorts, MCPH1 mutation is significantly associated with the RNA expression of many other genes, with 4,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCPH1-associated genes across cancer lineages are LINC01399, MMEL1-AS1, and ACTR3P2. Each is linked with MCPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCPH1-to-partner and partner-to-MCPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01399 grouped by MCPH1-low versus MCPH1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCPH1→partner) and Y-score (partner→MCPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01399 →	+0.641	+3.629	<.001	.008	3	3
LUSC	MMEL1-AS1 →	+0.803	+4.922	<.001	<.001	3	3
UCEC	ACTR3P2 →	+0.168	+1.962	<.001	.002	3	3
UCEC	RNU6-218P →	+0.424	+1.763	<.001	.001	3	3
LUSC	RNA5SP373 →	+0.340	+5.517	<.001	.001	3	3
SKCM	GSTA11P →	+0.018	+4.163	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

LINC01399 by MCPH1 expression — LUAD

Explore this box plot interactively →