MCOLN3

Across TCGA patient cohorts, MCOLN3 mutation is significantly associated with the RNA expression of many other genes, with 2,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCOLN3-associated genes across cancer lineages are RNU6-332P, LINC01943, and ISCA1P2. Each is linked with MCOLN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCOLN3-to-partner and partner-to-MCOLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-332P grouped by MCOLN3-low versus MCOLN3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN3→partner) and Y-score (partner→MCOLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-332P →	+0.303	+7.640	<.001	.009	3	3
UCEC	LINC01943 →	+0.351	+2.147	.002	<.001	3	2
LUSC	ISCA1P2 →	+0.146	+3.036	<.001	.006	3	2
UCEC	GCAT →	+0.544	+2.330	.001	<.001	3	2
UCEC	COPE →	+0.294	+2.627	.009	.005	3	2
UCEC	CREB3 →	+0.319	+1.900	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,314 associations by consensus.

RNU6-332P by MCOLN3 expression — BLCA

Explore this box plot interactively →