MCOLN3

Across TCGA patient cohorts, MCOLN3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCOLN3-associated genes across cancer lineages are PCNA, TIGAR, and Bcl-2. Each is linked with MCOLN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCOLN3-to-partner and partner-to-MCOLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MCOLN3-low versus MCOLN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN3→partner) and Y-score (partner→MCOLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.172	+1.321	.017	.029	3	3
UCEC	TIGAR →	+0.175	+2.228	<.001	<.001	3	2
UCEC	Bcl-2 →	-0.236	-1.565	.042	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.536	+1.584	.007	.009	3	2
UCEC	eEF2 →	+0.251	+1.700	.036	.040	3	1
UCEC	eIF4E →	+0.189	+3.335	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by MCOLN3 expression — UCEC

Explore this box plot interactively →