MCOLN2

Across TCGA patient cohorts, MCOLN2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCOLN2-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and G6PD. Each is linked with MCOLN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCOLN2-to-partner and partner-to-MCOLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MCOLN2-low versus MCOLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN2→partner) and Y-score (partner→MCOLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.397	+1.874	.005	.049	3	3
UCEC	Caspase-7-cleavedD198 →	+0.617	+2.604	.008	.005	3	3
SKCM	G6PD →	+0.208	+2.584	.032	.011	3	1
SKCM	p90 RSK →	+0.216	+2.584	.026	.011	3	1
UCEC	14-3-3_beta →	-0.086	-1.847	.030	.049	3	1
UCEC	EGFR_pY1068 →	-0.199	-1.584	.043	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ASNS by MCOLN2 expression — UCEC

Explore this box plot interactively →