MCOLN2

Across TCGA pan-cancer cohorts, MCOLN2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MCOLN2 data layer compared with 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MCOLN2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MCOLN2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

LUAD, SKCM, and CESC are the cancer types where MCOLN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.756	0.615	<.001	103	view →
SKCM	OS	Median	All	0.823	0.735	<.001	71	view →
CESC	OS	Tertile	II,III,IV	0.950	0.667	<.001	60	view →
UVM	DFS	Median	III,IV	0.348	0.731	.001	51	view →
LGG	DFS	Median	All	0.773	0.888	<.001	48	view →
ACC	DFS	Tertile	II,III,IV	0.742	0.440	.004	44	view →
KIRP	DFS	Median	II,III,IV	0.545	0.797	.005	36	view →
THYM	DFS	Quartile	All	0.743	0.970	.001	35	view →
PAAD	OS	Tertile	II,III,IV	0.715	0.494	.004	27	view →
LAML	DFS	Tertile	All	0.409	0.708	.009	26	view →
READ	OS	Tertile	III,IV	0.735	0.327	.016	16	view →
UCEC	OS	Tertile	II,III,IV	0.787	0.906	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MCOLN2–LUAD (OS)

Open the LUAD breakdown →