MCOLN2

Across TCGA cell cohorts, MCOLN2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCOLN2-associated genes across cancer lineages are NKX2-6, TLE7, and OR9I1. Each is linked with MCOLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCOLN2-to-partner and partner-to-MCOLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by MCOLN2-low versus MCOLN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN2→partner) and Y-score (partner→MCOLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
SKIN	OR9I1 →	+0.005	+5.022	<.001	.002	3	1
SKIN	AKR1C4 →	+0.132	+4.095	<.001	.009	3	1
SKIN	CEACAM16 →	+0.056	+5.217	<.001	<.001	3	1
SKIN	POTEB3 →	+0.043	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NKX2-6 by MCOLN2 expression — BLOOD_Leukemia

Explore this box plot interactively →