MCOLN1

Across TCGA patient cohorts, MCOLN1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,985 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MCOLN1-associated genes across cancer lineages are PRMT5, HSP90AB4P, and RPS10P14. Each is linked with MCOLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCOLN1-to-partner and partner-to-MCOLN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCOLN1 versus PRMT5 in OV, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN1→partner) and Y-score (partner→MCOLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRMT5 →	-0.387	-0.463	.004	.007	3	2
OV	HSP90AB4P →	+1.412	+0.732	.001	.002	3	2
HNSC	RPS10P14 →	-0.728	-0.430	.007	.001	3	2
HNSC	NDUFB4P2 →	-1.246	-0.565	<.001	<.001	3	2
HNSC	CENPJ →	-0.650	-0.453	.007	.001	3	2
PDAC	CEP112 →	+0.990	+0.622	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,985 associations by consensus.

MCOLN1 vs PRMT5 — OV

Explore this scatter interactively →