MCOLN1

Across TCGA patient cohorts, MCOLN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCOLN1-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and Bim. Each is linked with MCOLN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCOLN1-to-partner and partner-to-MCOLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MCOLN1-low versus MCOLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN1→partner) and Y-score (partner→MCOLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.258	+1.362	.041	.037	3	4
UCEC	Caspase-7-cleavedD198 →	+0.739	+2.019	<.001	.005	3	3
COAD	Bim →	+0.375	+2.815	.011	.036	3	2
COAD	Notch1 →	+0.203	+2.815	.046	.036	2	3
UCEC	eIF4E →	+0.187	+1.700	.012	.042	3	2
UCEC	JNK2 →	+0.297	+2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by MCOLN1 expression — UCEC

Explore this box plot interactively →