MCOLN1

Across TCGA cell cohorts, MCOLN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,988 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MCOLN1-associated GO terms across cancer lineages are Positive regulation of lysosome organization, Regulation of lysosome organization, and Calcium ion export. Each is linked with MCOLN1 in more than 17 cancer types. Because this analysis shows association rather than direction, both MCOLN1-to-partner and partner-to-MCOLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lysosome organization grouped by MCOLN1-low versus MCOLN1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN1→partner) and Y-score (partner→MCOLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of lysosome organization →	+0.156	+1.059	<.001	<.001	3	18
STOMACH	Regulation of lysosome organization →	+0.150	+0.929	<.001	<.001	3	17
OVARY	Calcium ion export →	+0.617	+0.739	.002	<.001	3	16
BLOOD_Myeloma	Vacuole organization →	+0.047	+1.179	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.082	+1.123	<.001	<.001	3	15
OESOPHAGUS	Iron ion transmembrane transport →	+0.114	+0.807	.002	.007	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

Positive regulation of lysosome organization by MCOLN1 expression — BLOOD_Myeloma

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