MCOLN1

Across TCGA cell cohorts, MCOLN1 mutation is significantly associated with the RNA expression of many other genes, with 531 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCOLN1-associated genes across cancer lineages are C19orf85, KRTAP19-5, and PRAMEF19. Each is linked with MCOLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCOLN1-to-partner and partner-to-MCOLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C19orf85 grouped by MCOLN1-low versus MCOLN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN1→partner) and Y-score (partner→MCOLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C19orf85 →	+0.255	+2.562	.005	.007	3	2
BLOOD_Lymphoma	KRTAP19-5 →	+0.047	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRAMEF19 →	+0.015	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KLK9 →	+0.026	+5.643	<.001	.002	3	1
BLOOD_Leukemia	IRS4 →	+0.029	+3.567	.001	.003	3	1
BLOOD_Leukemia	OR4D1 →	+0.166	+4.118	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

C19orf85 by MCOLN1 expression — LARGE_INTESTINE

Explore this box plot interactively →