MCMDC2

Across TCGA patient cohorts, MCMDC2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCMDC2-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and ASNS. Each is linked with MCMDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCMDC2-to-partner and partner-to-MCMDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MCMDC2-low versus MCMDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCMDC2→partner) and Y-score (partner→MCMDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.113	-2.000	.011	.030	3	2
UCEC	mTOR_pS2448 →	-0.185	-1.980	<.001	.030	3	2
UCEC	ASNS →	+0.297	+2.000	.028	.030	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.765	.013	.014	3	1
UCEC	eIF4E →	+0.221	+2.662	.005	<.001	3	1
UCEC	ERK2 →	+0.146	+1.415	.043	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

A-Raf_pS299 by MCMDC2 expression — UCEC

Explore this box plot interactively →