MCMDC2

Across TCGA pan-cancer cohorts, MCMDC2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MCMDC2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MCMDC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCMDC2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LUAD, KICH, and LIHC are the cancer types where MCMDC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCMDC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.651	<.001	11	view →
KICH	Female	II,III,IV	−1.010	<.001	8	view →
LIHC	Male	All	+0.658	<.001	8	view →
HNSC	All	All	+0.200	.006	7	view →
COAD	All	All	+0.318	<.001	6	view →
THCA	Male	All	−0.218	<.001	6	view →
CHOL	All	All	+0.632	<.001	5	view →
LUSC	All	All	+0.272	<.001	5	view →
STAD	All	All	+0.282	.009	4	view →
PRAD	All	All	+0.487	<.001	2	view →
KIRP	All	IV	+0.419	.030	2	view →
UCEC	All	All	−0.246	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MCMDC2–LUAD

Open the LUAD breakdown →