MCMDC2

Across TCGA cell cohorts, MCMDC2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCMDC2-associated genes across cancer lineages are PRR32, SUCNR1, and PSMB11. Each is linked with MCMDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCMDC2-to-partner and partner-to-MCMDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR32 grouped by MCMDC2-low versus MCMDC2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCMDC2→partner) and Y-score (partner→MCMDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRR32 →	+0.224	+4.714	<.001	.002	3	1
LARGE_INTESTINE	SUCNR1 →	+0.134	+3.665	.004	.004	3	1
LARGE_INTESTINE	PSMB11 →	+0.019	+3.141	.004	.002	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.001	3	1
LARGE_INTESTINE	CD300H →	+0.027	+3.678	<.001	.001	3	1
SKIN	SLC10A2 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRR32 by MCMDC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →