MCM8

Across TCGA patient cohorts, MCM8 mutation is significantly associated with the RNA expression of many other genes, with 2,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM8-associated genes across cancer lineages are CYCSP22, ZUP1, and MED27. Each is linked with MCM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM8-to-partner and partner-to-MCM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP22 grouped by MCM8-low versus MCM8-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM8→partner) and Y-score (partner→MCM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CYCSP22 →	+0.206	+5.421	<.001	.005	3	2
UCEC	ZUP1 →	+0.421	+3.502	.005	.002	3	2
UCEC	MED27 →	+0.454	+3.892	<.001	<.001	3	2
UCEC	KLHL21 →	+0.473	+2.716	.002	.003	3	2
UCEC	MRPS18C →	+0.427	+2.108	<.001	.003	3	2
UCEC	AIMP1 →	+0.645	+3.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,586 associations by consensus.

CYCSP22 by MCM8 expression — READ

Explore this box plot interactively →