MCM8

Across TCGA cell cohorts, MCM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,912 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MCM8-associated GO terms across cancer lineages are Protein localization to chromosome, Cell cycle DNA replication, and DNA-templated DNA replication. Each is linked with MCM8 in more than 19 cancer types. Because this analysis shows association rather than direction, both MCM8-to-partner and partner-to-MCM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to chromosome grouped by MCM8-low versus MCM8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM8→partner) and Y-score (partner→MCM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein localization to chromosome →	+0.120	+1.267	.003	.002	3	20
PANCREAS	Cell cycle DNA replication →	+0.137	+0.762	.001	.001	3	20
PANCREAS	DNA-templated DNA replication →	+0.131	+1.009	<.001	<.001	3	20
BONE	DNA strand elongation involved in DNA replication →	+0.179	+1.205	.001	.001	3	20
BONE	Mitotic sister chromatid segregation →	+0.142	+1.344	<.001	<.001	3	19
BONE	Spindle organization →	+0.096	+1.111	.002	.004	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,912 associations by consensus.

Protein localization to chromosome by MCM8 expression — OESOPHAGUS

Explore this box plot interactively →