MCM8

Across TCGA cell cohorts, MCM8 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM8-associated genes across cancer lineages are TCERG1L, BPIFB6, and ACCSL. Each is linked with MCM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM8-to-partner and partner-to-MCM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCERG1L grouped by MCM8-low versus MCM8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM8→partner) and Y-score (partner→MCM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCERG1L →	+1.051	+3.388	.001	.002	3	2
PANCREAS	BPIFB6 →	+0.086	+5.000	<.001	.006	3	1
PANCREAS	ACCSL →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	MTRNR2L5 →	+0.026	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUAD	DAO →	+0.087	+3.787	.008	.004	3	1
LUNG_NSCLC_LUAD	CACNA1S →	+0.612	+3.807	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TCERG1L by MCM8 expression — BLOOD_Leukemia

Explore this box plot interactively →