MCM5

Across TCGA patient cohorts, MCM5 mutation is significantly associated with the RNA expression of many other genes, with 3,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM5-associated genes across cancer lineages are CCDC163, RNU6-994P, and LINC02758. Each is linked with MCM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM5-to-partner and partner-to-MCM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC163 grouped by MCM5-low versus MCM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM5→partner) and Y-score (partner→MCM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC163 →	+0.382	+2.938	.003	<.001	3	2
LUSC	RNU6-994P →	+0.238	+4.578	<.001	.005	3	2
SKCM	LINC02758 →	+0.067	+3.224	.006	.001	3	2
HNSC	KCNQ2-AS1 →	+0.139	+5.822	<.001	.003	3	2
UCEC	DCP1A →	+0.454	+2.526	.001	.001	3	2
UCEC	PIGW →	+0.647	+3.180	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,491 associations by consensus.

CCDC163 by MCM5 expression — UCEC

Explore this box plot interactively →